Thyroid dysfunction in sea bass (Dicentrarchus labrax): underlying mechanisms and effects of polychlorinated biphenyls on thyroid hormone physiology and metabolism.
نویسندگان
چکیده
The current study examines the effect of subchronic exposure to a mixture of Aroclor standards on thyroid hormone physiology and metabolism in juvenile sea bass. The contaminant mixture was formulated to reflect the persistent organic pollution to which the European sea bass population could conceivably be exposed (0.3, 0.6 and 1.0 μg Σ7PCBs per g food pellets) and higher (10 μg Σ7PCBs per g food pellets). After 120 days of exposure, histomorphometry of thyroid tissue, muscular thyroid hormone concentration and activity of enzymes involved in metabolism of thyroid hormones were assessed. Mean concentrations of 8, 86, 142, 214 and 2279 ng g(-1)ww (Σ7 ICES PCB congeners) were determined after 120 days exposure. The results show that the effects of PCB exposures on the thyroid system are dose-dependent. Exposure to environmentally relevant doses of PCB (0.3-1.0 μg Σ7PCBs per g food pellets) induced a larger variability of the follicle diameter and stimulated hepatic T(4) outer ring deiodinase. Muscular thyroid hormone levels were preserved thanks to the PCB induced changes in T(4) dynamics. At 10 times higher concentrations (10 μg Σ7PCBs per g food pellets) an important depression of T(3) and T(4) levels could be observed which are apparently caused by degenerative histological changes in the thyroid tissue.
منابع مشابه
Effects of persistent organic pollutants on the thyroid function of the European sea bass (Dicentrarchus labrax) from the Aegean sea, is it an endocrine disruption?
We evaluated the alterations of organochlorinated compounds such as polychlorobiphenyls (PCB), dichloro-diphenyl-dichloroethylene (DDE) and dichloro-diphenyl-trichloroethane (DDT) on the thyroid in wild and cultured sea bass (Dicentrarchus labrax) at environmental concentrations. These compounds influence the endocrine system of many fish species and are qualified as endocrine disruptors. The t...
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ورودعنوان ژورنال:
- Aquatic toxicology
دوره 105 3-4 شماره
صفحات -
تاریخ انتشار 2011